2016 grant award


In 2016 the Foundation awarded the following grant.

2016 equipment award

Principal Investigator: Professor Amrita Ahluwalia and Professors Thiemermann, Hobbs, Yaqoob, Tinker, Suzuki, Brohi, Marelli-Berg, Kelsell, Mathur, WHRI
Study title: An echocardiographic imaging facility

  • Award: £100,000

Heart failure is a common, debilitating and ultimately fatal condition with almost 50% of patients dying within 5 years of diagnosis. Current therapies for chronic heart failure are limited and do not modify disease progression. Several groups within the William Harvey Research Institute have identified novel molecular mechanisms (drug targets) that may be valuable for heart muscle protection, and for which new molecules could be developed or existing medicines repurposed; many we hope to evaluate in clinical trials within the Barts Heart Centre. Prior to clinical evaluation we need to test these unique targets in experimental models using validated, state-of-the-art technology that has relevance, and translates well, to the clinical setting. This grant supports the acquisition of the latest technology for assessment of cardiac function (high-fidelity ultrasound echocardiography), akin to that used in clinical assessment. The VisualSonics Vevo 3100 system permits cutting-edge measurement and 4-dimensional modelling of heart structure & function in rodents; these sophisticated capabilities enable innovative approaches to be evaluated efficiently and definitively. Identification of novel, disease-modifying therapeutics should dramatically improve the mortality and disability associated with heart failure, improving the quality of life for millions of patients and lowering healthcare costs.

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